Program
Redox Week in Sendai Sep 9–14, 2019
Tohoku University Seiryo Auditorium
Sep 9-11
1st International Persulfide Conference
Sep 11-12
1st STINT-JSPS Joint Symposium
Sep 12-14
The Environmental Response V /17th JBS Biofrontier Symposium
The 1st International Conference on Persulfide and Sulfur Metabolism in Biology and Medicine
September 9 (Mon)
8:45-8:55 Opening Remarks
Takaaki Akaike (Tohoku University)
8:55-11:05 Session I: Chemistry and Chemical Biology
(Chair: Takaaki Akaike)
S-1-1 Control of protein function through oxidation and reduction of persulfidated states
8:55 Péter Nagy (National Institute of Oncology)
S-1-2 Are reactive sulfur species the new reactive oxygen species?
9:25 Kenneth R. Olson (Indiana University School of Medicine)
S-1-3 The interaction of persulfides with metals and metalloproteins
9:55 Jon M. Fukuto (Sonoma State University)
S-1-4 The protective effects of per- and poly-sulfides in cellular systems
10:25 Joseph Lin (Sonoma State University)
S-1-5 The chemical biology of per- and poly-sulfides: Realizing their potential biologic function
and therapeutic utility
10:50 Christopher L. McGinity (National Cancer Institute)
11:15-12:40 Session II: Signal Functions-1
(Chair: Péter Nagy)
S-2-1 A screen for small molecule regulators of cellular hydrogen sulfide levels reveals genotoxic
stress as a major activator of endogenous H2S production
11:15 James R. Mitchell (Harvard T.H. Chan School of Public Health)
S-2-2 Red blood cells play a role in systemic sulfide metabolism
11:45 Miriam M. Cortese-Krott (Heinrich Heine University Düsseldorf)
S-2-3 Mitochondria-specific SQR knock-out mice cause lethal impairment of sulfur respiration.
12:15 Masanobu Morita (Tohoku University)
13:40-15:30 Session III: Signal Functions-2
(Chair: Miriam M. Cortese-Krott)
S-3-1 Persulfide signaling in LPS-initiated macrophage response
13:40 Yasuo Watanabe (Showa Pharmaceutical University)
S-3-2 Protein disulfide linkages as a target of oxidation
14:05 Koji Uchida (The University of Tokyo)
S-3-3 Integrating redox homeostasis and protein persulfidation activities of the thioredoxin system,
the glutathione system, and the transsulfuration pathway
14:30 Edward E. Schmidt (Montana State University)
S-3-4 Protein kinase G oxidation as a mediator of signalling induced by hydrogen sulfide and related
molecular species
15:00 Philip Eaton（Queen Mary University of London)
15:40-17:45 Session IV: Stress Response and Diseases
(Chair: Martin Feelisch)
S-4-1 Genetic deficiency of 3-mercaptopyruvate sulfur transferase impairs mitochondrial function
and exacerbates heart failure
15:40 David J. Lefer (Louisiana State University School of Medicine)
S-4-2 Protein cysteine persulfide regulates mitochondrial quality and stress resistance of the
heart against environmental stress
16:10 Motohiro Nishida (National Institute for Physiological Science)
S-4-3 Fundamental role of sulfur modification of RNA in protein translation and its implication in
human diseases
16:35 Fan-Yan Wei (Kumamoto University)
S-4-4 Development of anti-oxidative intraocular irrigating solution based on reactive persulfides
17:00 Hiroshi Kunikata (Tohoku University)
S-4-5 Disruption of reactive persulfide-dependent redox signal by exposure of electrophile in
neuronal cells
17:25 Shingo Kasamatsu (Osaka Prefecture University)
17:50-18:20 Super Short Talk：Young Scientists Oral SessionⅠ
(Chair: Akira Nishimura)
SS1-1 Positive regulation of protein-disulfide isomerase activity via S-persulfidation
Honami Ushirokawa (Okayama University)
SS1-2 Characterization of cysteine persulfide synthases in plant cells and cyanobacteria
Kota Kera (Tohoku University)
SS1-3 Chronological aging regulated by persulfide production via mitochondrial
cysteinyl-tRNA synthetase expression depending on energy metabolism in yeast
Sunghyeon Yoon (Tohoku University)
SS1-4 Longevity regulation via sulfide: quinone oxidoreductase-dependent energy metabolism
in fission yeast
Qamarul Hafiz Zainol Abidin (Tohoku University)
18:20-18:50 Super Short Talk：Young Scientists Oral SessionⅡ
(Chair: Hideshi Ihara)
SS2-1 The obligatory role of the S-sulfuration in reversibility of PTP1B activity
Yumi Abiko (University of Tsukuba)
SS2-2 Phase-zero reaction as a primary defense systeme against electrophilic stress in
out of cell: Involvement of reactive persulfides
Masahiro Akiyama (University of Tsukuba)
SS2-3 Nrf2 and CSE act as critical molecules in parallel pathways for repression of
environmental electrophile-mediated toxicity in mice
Yasuhiro Shinkai (University of Tsukuba)
September 10 (Tue)
9:00-11:40 Session V: Signal Function-3
(Chair: Hozumi Motohashi and Tomohiro Sawa)
S-5-1 Sulfur and the stress of life – What may be the role of persulfides?
9:00 Martin Feelisch (University of Southampton)
S-5-2 Use of the purple photosynthetic bacterium Rhodobacter capsulatus as a model to study persulfide
metabolism and signaling
9:30 Shinji Masuda (Tokyo Institute of Technology)
S-5-3 Pivotal role of sulfide catabolism in hypoxia tolerance
9:55 Fumito Ichinose (Harvard Medical School)
S-5-4 Role of sulfane sulfur in metallothionein-3 as a model zinc-binding protein
10:25 Yoshito Kumagai (University of Tsukuba)
S-5-5 Promotion of osteoclast differentiation by reactive sulfur species
10:50 Yoichi Miyamoto (Showa University)
S-5-6 Maintenance of ER homeostasis through disulfide reductase
11:15 Ryo Ushioda (Kyoto Sangyo University)
11:50-12:50 Luncheon Seminar
BCRquest.com：Healthcare Network as Big Data - world wide and Japanese potential
Hiroyuki Iwama (BC Platforms K. K)
BCRquest.com：ビッグデータとしてのヘルスケアネットワーク- World wideと日本の可能性
岩間 裕之（BCプラットフォーム株式会社 COO）
13:00-15:50 Session VI: Sulfur Methodology
(Chair: Jon M. Fukuto)
S-6-1 Persulfide regulation: Chemistry and chemical biology
13:00 Ming Xian (Washington State University)
S-6-2 Development of fluorescent probes for H2S and sulfane sulfur and their application to
the inhibitor screening
13:30 Kenjiro Hanaoka (The University of Tokyo)
S-6-3 Fluorescent probes for selective and reversible imaging of reactive sulfur species
13:50 Keitaro Umezawa (Tokyo Metropolitan Institute of Gerontology)
S-6-4 Chemical tools for sulfur: caged hydrogen sulfide and fluorescence probe for cysteine persulfide
14:10 Hidehiko Nakagawa (Nagoya City University)
S-6-5 Quantitative determination of polysulfide in plasma proteins and biological human
fluids using a novel ‘Sulfide elimination from polysulfide’ (SEP) method
14:35 Yu Ishima (Tokushima University)
S-6-6 Raman scattering techniques and their application to intracellular detection and
imaging of persulfides and other polysulfur species
14:55 Sumeet Mahajan (University of Southampton)
S-6-7 Raman imaging: application to detect water and biological molecules within a single cell
15:25 Takakazu Nakabayashi (Tohoku University)
16:00-16:55 Session VII: Inflammation and Cancer Metabolism
(Chair: Albert van der Vliet)
S-7-1 NOS2 and COX2 as major drivers of poor outcome in ER- breast cancer.
New therapeutic opportunities in a difficult disease.
16:00 David A. Wink (National Cancer Institute)
S-7-2 Gaseous molecules as an endogenous factor in the inflammation-related carcinogenesis model
16:30 Futoshi Okada (Tottori University)
September 11 (Wed)
8:45-10:30 Session VIII: Inflammation and Immunity
(Chair: Philip Eaton)
S-8-1 The NADPH oxidase DUOX1 mediates innate allergen responses and
type 2 inflammation: Implications for allergic asthma and metabolic disease
8:45 Albert van der Vliet (University of Vermont)
S-8-2 N-Acetyl-L-cystine polysulfides act as potent persulfide/polysulfide donors and
ameliorate lethal endotoxin shock via their anti-inflammatory effects
9:15 Tomohiro Sawa (Kumamoto University)
S-8-3 Roles of CARS2/CPERS in the elastase-induced pulmonary emphysema and
the pathophysiology of COPD
9:40 Hisatoshi Sugiura (Tohoku University)
S-8-4 Deficiency of CARS2, a principal cysteine persulfide synthetase, aggravated house dust
mite-induced allergic inflammation in a mouse model of bronchial asthma
10:05 Mitsuhiro Yamada (Tohoku University)
10:30-10:40 Closing Remarks
Hozumi Motohashi (Tohoku University)
1st STINT-JSPS Joint Symposium in Sendai
15:00-15:30 Opening Ceremony
Opening Speech:
YAMAMOTO, Masayuki (Tohoku University)
Guest Speech:
ISOGAI, Keisuke
(Director General, National Institute of Science and Technology Policy, NISTEP)
YAEGASHI, Nobuo
(Dean, Tohoku University Graduate School of Medicine)
15:30-16:10 Special Lecture 1:
Reactive persulfide mediates versatile redox signal functions with canonical signaling mimetics
AKAIKE, Takaaki (Tohoku University)
16:25-17:10 Special Lecture 2:
Multiple cellular effects upon drug targeting of the selenoprotein thioredoxin reductase 1 (TrxR1, TXNRD1) in cancer
ARNER, Elias S.J. (Karolinska Institutet)
17:15-17:55 Special Lecture 3:
On-tissue visualization of polysulfides as a biomarker predicting platinum-based chemosensitivity after debulking surgery of ovarian cancer
SUEMATSU, Makoto (AMED/Keio University)
18:00-20:00 Round-Table Discussion